Molecular Formula | C24H31ClN3O5P |
Molar Mass | 507.95 |
Solubility | 10 mM in DMSO |
Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
In vivo study | The monkeys (Treated with Plasmodium knowlesi ) are treated i.g. once daily for 3 days with 6 or 10 mg/kg of Naphthoquine phosphate respectively. At 24 h after Naphthoquine phosphate administration, the parasite reduction rate is higher than 90%. |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 1.65 ml | 8.252 ml | 16.503 ml |
5 mM | 0.33 ml | 1.65 ml | 3.301 ml |
10 mM | 0.165 ml | 0.825 ml | 1.65 ml |
5 mM | 0.033 ml | 0.165 ml | 0.33 ml |
This product contains naphthoquine phosphate (C24H28N3OCl • 2H3PO4 • 2H2O) and artemisinin (C15H2205) should be 90.0% ~ 110.0% of the label amount.
naphthoquine phosphate (equivalent to naphthoquine) 78.3g(50g ) 156.6g( 100g)
Artemisinin 125g 250g
Appropriate amount of excipients
Made of 1000 tablets 1000 tablets
This product is a light yellow tablet or film-coated tablet, which shows a light yellow color after removing the coating.
antimalarial drugs.
sealed and stored in a dry place.
biological activity | Naphthoquine phosphate is an effective antimalarial agent with oral activity. Naphthoquine phosphate has a complete killing function against the schizonts of a variety of plasmodium, including the resistance of Plasmodium falciparum to chloroquine. |